Regulonix

Non-opioid drugs for chronic pain to attack a global health epidemic

Regulonix UAVC

Regulonix was founded to address the growing opioid epidemic. Our science approaches the issue of treating pain in an entirely new way that is targeted and highly selective, resulting in non-addictive solutions.

Focusing on a validated biologic pain target with a unique mechanism of action. Regulonix is an early-stage biotechnology company developing non-opioid therapeutics that relieve chronic pain. By indirectly targeting the well-established and genetically validated pain target NaV1.7 sodium channel and focusing on the signaling pathways that control channel activity, the Regulonix team has isolated compounds demonstrated in animal models to be non-addictive and more effective than morphine. This unique platform helps address a global pain management therapeutics market projected to reach $83B by 2024, affecting more than 100 million Americans and 1.5 billion people globally.

Over 11.5 million Americans annually misuse prescription opioids, with 115 people dying each day from overdoses. This public health emergency is widely recognized by government agencies, including the CDC and FDA, as an urgent problem and one of their highest priorities.

Company Overview
  • Revolutionary non-opioid pain medication
  • Non-addictive and more effective than morphine
  • Targets the well-established and genetically validated pain target NaV1.7 sodium channel and the signaling pathways that control channel activity
Traction
  • Collaborating on an exclusive license with the NIH, Regulonix has identified four pre-clinical candidates for advancement into clinical trials
  • Regulonix was recognized in a 2024 article in Scientific American magazine about the novel application and non-addictive potential of a non-opiate pain killer leveraging the Sodium channel to treat severe pain
  • Actively in discussions for advancement into human clinical trials